Vaginal moniliasis after treatment of trichomonal infection with "Flagyl".

There is some difference of opinion regarding the incidence of vaginal thrush following the treatment of trichomonal vaginitis with the new oral trichomonicide, metronidazole ("Flagyl"). Rees (1960) and Rodin, King, Nicol, and Barrow (1960) concluded that metronidazole neither encouraged nor inhibited the growth of the fungus concerned. Watt and Jennison (1960) found coincident monilial infection unaffected by treatment. Moffett and McGill (1960), on the other hand, noted that Candida might be encouraged; three of their 42 patients showed the fungus after treatment, and symptoms were severe or moderately severe in two. Whitehouse and Porteous (1962) stated that several cases of monilial vulvo-vaginitis had been seen after treatment of Trichomonas vaginalis infection with an oral trichomonicide, presumably "Flagyl". None of these reports compares the incidence of moniliasis before and after metronidazole treatment, and this retrospective study attempts to fill this gap. The incidence of vaginal moniliasis, before and after Flagyl or local Stovarsol treatment, is compared, and comparison is also made with a control group.